The temple of Asclepius is located in the middle of the San Gregorio plane. Its identification is based on a mention by Polybius (I, 18, 2), who states that the temple was "in front of the city", one mile away. However, as the actual distance does not correspond and the size of the building is relatively small, scholars remains dubious about this attribution.
The small temple, probably dating to the late 5th century BC and measuring 21.7 x 10.7 m, rises over a basement with three steps. Its peculiarity is the fake opysthodomus with two semi-columns in the external side of the rear cella. Also extant are parts of the entablature, with lion-like protomes, a frieze and a geison pediment.
The Temple of Asklepios is outside the city in the center of the plain of St. Gregorius, almost at the confluence of the rivers Akragas and Hypsas. It is almost certainly the temple mentioned by Polybios (1.18) in his description of the Roman siege in 262 B.C. According to Cicero (Verr. 2.4.43) it contained a statue of Apollo by Myron, stolen by Verres. This small temple of the second half of the 5th c. B.C. is built on a high podium; it is Doric, in antis (21.7 x 10.7 m) with pronaos, cella, and a false opisthodomos formed by a solid wall decorated with two Doric half-columns in between corner pilasters.